# BioMysteryBench Human Difficult (BioMysteryBench (human-difficult))

> Computational biology challenges with objective answers that remained unsolved by independent human experts.

Canonical page: https://benchlm.ai/benchmarks/biomysterybenchhumandifficult

- Category: [Knowledge](/knowledge)
- Last updated: September 27, 2026

## About BioMysteryBench (human-difficult)

- Year: 2026
- Tasks: Human-difficult computational biology investigations
- Format: Task score
- Difficulty: Frontier computational biology
- Paper: [Claude Opus 5 System Card](https://www-cdn.anthropic.com/c5fbac3f0b1280a933ebd26d3cb8bb9f5bdeaf48/Claude%20Opus%205%20System%20Card.pdf)

Section 8.17.1 reports the provider's revised human-difficult subset after removing six problems based on external feedback.

BioMysteryBench (human-difficult) is currently displayed on BenchLM for reference, but it is excluded from the weighted scoring formula.

## Leaderboard (5 models)

| Rank | Model | Creator | Score |
|------|-------|---------|-------|
| 1 | [Gemini 3.8 Flash](/models/gemini-3-8-flash) | Google | 56.5% |
| 2 | [Claude Opus 5.5](/models/claude-opus-5-5) | Anthropic | 50.0% |
| 3 | [Claude Opus 5](/models/claude-opus-5) | Anthropic | 49.4% |
| 4 | [Gemini 3.7 Flash](/models/gemini-3-7-flash) | Google | 43.5% |
| 5 | [Apodex 1.1](/models/apodex-1-1) | Apodex | 35.3% |

## FAQ

### What does BioMysteryBench (human-difficult) measure?

Computational biology challenges with objective answers that remained unsolved by independent human experts.

### Which model scores highest on BioMysteryBench (human-difficult)?

Gemini 3.8 Flash by Google currently leads with a score of 56.5% on BioMysteryBench (human-difficult).

### How many models are evaluated on BioMysteryBench (human-difficult)?

5 AI models have been evaluated on BioMysteryBench (human-difficult) on BenchLM.

### Does BioMysteryBench (human-difficult) affect BenchLM's overall score?

Not directly. BioMysteryBench (human-difficult) is still displayed on BenchLM for reference, but it is excluded from the weighted scoring formula.

## Compare Top Models on BioMysteryBench (human-difficult)

- [Gemini 3.8 Flash vs Claude Opus 5.5](/compare/claude-opus-5-5-vs-gemini-3-8-flash)
- [Claude Opus 5.5 vs Claude Opus 5](/compare/claude-opus-5-vs-claude-opus-5-5)
- [Claude Opus 5 vs Gemini 3.7 Flash](/compare/claude-opus-5-vs-gemini-3-7-flash)
- [Gemini 3.7 Flash vs Apodex 1.1](/compare/apodex-1-1-vs-gemini-3-7-flash)