# BioMysteryBench Human Solvable (BioMysteryBench (human-solvable))

> Computational biology challenges that independent human experts were able to solve.

Canonical page: https://benchlm.ai/benchmarks/biomysterybenchhumansolvable

- Category: [Knowledge](/knowledge)
- Last updated: September 27, 2026

## About BioMysteryBench (human-solvable)

- Year: 2026
- Tasks: Human-solvable computational biology investigations
- Format: Task score
- Difficulty: Expert computational biology
- Paper: [Claude Opus 5 System Card](https://www-cdn.anthropic.com/c5fbac3f0b1280a933ebd26d3cb8bb9f5bdeaf48/Claude%20Opus%205%20System%20Card.pdf)

Section 8.17.1 reports the provider's revised human-solvable subset after removing three problems based on external feedback.

BioMysteryBench (human-solvable) is currently displayed on BenchLM for reference, but it is excluded from the weighted scoring formula.

## Leaderboard (4 models)

| Rank | Model | Creator | Score |
|------|-------|---------|-------|
| 1 | [Claude Opus 5](/models/claude-opus-5) | Anthropic | 90.1% |
| 2 | [Claude Opus 5.5](/models/claude-opus-5-5) | Anthropic | 89.3% |
| 3 | [Gemini 3.8 Flash](/models/gemini-3-8-flash) | Google | 88.8% |
| 4 | [Gemini 3.7 Flash](/models/gemini-3-7-flash) | Google | 87.1% |

## FAQ

### What does BioMysteryBench (human-solvable) measure?

Computational biology challenges that independent human experts were able to solve.

### Which model scores highest on BioMysteryBench (human-solvable)?

Claude Opus 5 by Anthropic currently leads with a score of 90.1% on BioMysteryBench (human-solvable).

### How many models are evaluated on BioMysteryBench (human-solvable)?

4 AI models have been evaluated on BioMysteryBench (human-solvable) on BenchLM.

### Does BioMysteryBench (human-solvable) affect BenchLM's overall score?

Not directly. BioMysteryBench (human-solvable) is still displayed on BenchLM for reference, but it is excluded from the weighted scoring formula.

## Compare Top Models on BioMysteryBench (human-solvable)

- [Claude Opus 5 vs Claude Opus 5.5](/compare/claude-opus-5-vs-claude-opus-5-5)
- [Claude Opus 5.5 vs Gemini 3.8 Flash](/compare/claude-opus-5-5-vs-gemini-3-8-flash)
- [Gemini 3.8 Flash vs Gemini 3.7 Flash](/compare/gemini-3-7-flash-vs-gemini-3-8-flash)