# Axiom Bio morphology-to-molecule matching (Morphology-to-molecule matching)

> Matches multi-channel cellular imaging data to the molecule-dose perturbations that produced it.

Canonical page: https://benchlm.ai/benchmarks/morphologytomolecule

- Category: [Knowledge](/knowledge)
- Last updated: September 27, 2026

## About Morphology-to-molecule matching

- Year: 2026
- Tasks: Four multi-channel cell-imaging perturbation-matching tasks
- Format: Matching accuracy
- Difficulty: Biomedical image and molecular reasoning
- Paper: [Claude Opus 5.5 System Card](https://www-cdn.anthropic.com/fc1b44717c85dc068bc6ba5024219938094694bd/Claude%20Opus%205.5%20System%20Card.pdf)

Section 8.17.3 reports a provider-run result in a closed sandbox with imaging data, code execution, and no network access. It is display-only evidence.

Morphology-to-molecule matching is currently displayed on BenchLM for reference, but it is excluded from the weighted scoring formula.

## Leaderboard (1 models)

| Rank | Model | Creator | Score |
|------|-------|---------|-------|
| 1 | [Claude Opus 5.5](/models/claude-opus-5-5) | Anthropic | 34.0% |

## FAQ

### What does Morphology-to-molecule matching measure?

Matches multi-channel cellular imaging data to the molecule-dose perturbations that produced it.

### Which model scores highest on Morphology-to-molecule matching?

Claude Opus 5.5 by Anthropic currently leads with a score of 34.0% on Morphology-to-molecule matching.

### How many models are evaluated on Morphology-to-molecule matching?

1 AI models have been evaluated on Morphology-to-molecule matching on BenchLM.

### Does Morphology-to-molecule matching affect BenchLM's overall score?

Not directly. Morphology-to-molecule matching is still displayed on BenchLM for reference, but it is excluded from the weighted scoring formula.