# Anthropic de novo protein-binder design evaluation (De novo protein-binder design)

> Designs diverse miniprotein binders against target protein structures in a GPU-equipped research sandbox.

Canonical page: https://benchlm.ai/benchmarks/proteinbinderdesign

- Category: [Knowledge](/knowledge)
- Last updated: September 27, 2026

## About De novo protein-binder design

- Year: 2026
- Tasks: 15 protein targets
- Format: Composite structural design score
- Difficulty: Long-horizon computational protein design
- Paper: [Claude Opus 5.5 System Card](https://www-cdn.anthropic.com/fc1b44717c85dc068bc6ba5024219938094694bd/Claude%20Opus%205.5%20System%20Card.pdf)

Section 8.17.6 reports the mean over 15 protein targets and five independent runs per target. It is display-only, model-plus-tool-system evidence.

De novo protein-binder design is currently displayed on BenchLM for reference, but it is excluded from the weighted scoring formula.

## Leaderboard (1 models)

| Rank | Model | Creator | Score |
|------|-------|---------|-------|
| 1 | [Claude Opus 5.5](/models/claude-opus-5-5) | Anthropic | 82.6% |

## FAQ

### What does De novo protein-binder design measure?

Designs diverse miniprotein binders against target protein structures in a GPU-equipped research sandbox.

### Which model scores highest on De novo protein-binder design?

Claude Opus 5.5 by Anthropic currently leads with a score of 82.6% on De novo protein-binder design.

### How many models are evaluated on De novo protein-binder design?

1 AI models have been evaluated on De novo protein-binder design on BenchLM.

### Does De novo protein-binder design affect BenchLM's overall score?

Not directly. De novo protein-binder design is still displayed on BenchLM for reference, but it is excluded from the weighted scoring formula.