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Claude Opus 4.5 vs GPT-4.1 nano

Head-to-head comparison across 2benchmark categories. Overall scores shown here use BenchLM's provisional ranking lane.

Claude Opus 4.5

77

VS

GPT-4.1 nano

27

1 categoriesvs1 categories

Verified leaderboard positions: Claude Opus 4.5 #9 · GPT-4.1 nano unranked

Pick Claude Opus 4.5 if you want the stronger benchmark profile. GPT-4.1 nano only becomes the better choice if instruction following is the priority or you want the cheaper token bill.

Category Radar

Head-to-Head by Category

Category Breakdown

Knowledge

Claude Opus 4.5
66.2vs50.3

+15.9 difference

Inst. Following

GPT-4.1 nano
79.4vs83.2

+3.8 difference

Operational Comparison

Claude Opus 4.5

GPT-4.1 nano

Price (per 1M tokens)

$5 / $25

$0.1 / $0.4

Speed

46 t/s

181 t/s

Latency (TTFT)

1.01s

0.63s

Context Window

200K

1M

Quick Verdict

Pick Claude Opus 4.5 if you want the stronger benchmark profile. GPT-4.1 nano only becomes the better choice if instruction following is the priority or you want the cheaper token bill.

Claude Opus 4.5 is clearly ahead on the provisional aggregate, 77 to 27. The gap is large enough that you do not need to squint at the spreadsheet to see the difference.

Claude Opus 4.5's sharpest advantage is in knowledge, where it averages 66.2 against 50.3. The single biggest benchmark swing on the page is GPQA, 87% to 50.3%. GPT-4.1 nano does hit back in instruction following, so the answer changes if that is the part of the workload you care about most.

Claude Opus 4.5 is also the more expensive model on tokens at $5.00 input / $25.00 output per 1M tokens, versus $0.10 input / $0.40 output per 1M tokens for GPT-4.1 nano. That is roughly 62.5x on output cost alone. GPT-4.1 nano gives you the larger context window at 1M, compared with 200K for Claude Opus 4.5.

Benchmark Deep Dive

Frequently Asked Questions (3)

Which is better, Claude Opus 4.5 or GPT-4.1 nano?

Claude Opus 4.5 is ahead on BenchLM's provisional leaderboard, 77 to 27. The biggest single separator in this matchup is GPQA, where the scores are 87% and 50.3%.

Which is better for knowledge tasks, Claude Opus 4.5 or GPT-4.1 nano?

Claude Opus 4.5 has the edge for knowledge tasks in this comparison, averaging 66.2 versus 50.3. Inside this category, GPQA is the benchmark that creates the most daylight between them.

Which is better for instruction following, Claude Opus 4.5 or GPT-4.1 nano?

GPT-4.1 nano has the edge for instruction following in this comparison, averaging 83.2 versus 79.4. Inside this category, IFEval is the benchmark that creates the most daylight between them.

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Last updated: April 24, 2026

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