Side-by-side benchmark comparison across knowledge, coding, math, and reasoning.
o3-pro is clearly ahead on the aggregate, 77 to 28. The gap is large enough that you do not need to squint at the spreadsheet to see the difference.
o3-pro's sharpest advantage is in knowledge, where it averages 75 against 71.4. The single biggest benchmark swing on the page is HumanEval, 80 to 54.8.
o3-pro is the reasoning model in the pair, while Mixtral 8x22B Instruct v0.1 is not. That usually helps on harder chain-of-thought-heavy tests, but it can also mean more latency and more token spend in real use. o3-pro gives you the larger context window at 200K, compared with 64K for Mixtral 8x22B Instruct v0.1.
Pick o3-pro if you want the stronger benchmark profile. Mixtral 8x22B Instruct v0.1 only becomes the better choice if you would rather avoid the extra latency and token burn of a reasoning model.
o3-pro
75
Mixtral 8x22B Instruct v0.1
71.4
o3-pro
56.7
Mixtral 8x22B Instruct v0.1
54.8
o3-pro is ahead overall, 77 to 28. The biggest single separator in this matchup is HumanEval, where the scores are 80 and 54.8.
o3-pro has the edge for knowledge tasks in this comparison, averaging 75 versus 71.4. Inside this category, MMLU is the benchmark that creates the most daylight between them.
o3-pro has the edge for coding in this comparison, averaging 56.7 versus 54.8. Inside this category, HumanEval is the benchmark that creates the most daylight between them.
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