Benchmark profile
BioMysteryBench Human Difficult (BioMysteryBench (human-difficult))
Computational biology challenges with objective answers that remained unsolved by independent human experts.
Data verifiedBenchmark score on BioMysteryBench (human-difficult) — July 24, 2026
BenchLM mirrors the published score view for BioMysteryBench (human-difficult). Claude Opus 5 leads the public snapshot at 49.4%. BenchLM does not use these results to rank models overall.
Benchmark score table (1 model)
ScoreAbout BioMysteryBench (human-difficult)
Year
2026
Tasks
Human-difficult computational biology investigations
Format
Task score
Difficulty
Frontier computational biology
Section 8.17.1 reports the provider's revised human-difficult subset after removing six problems based on external feedback.
BenchLM freshness & provenance
Version
BioMysteryBench (human-difficult) 2026
Refresh cadence
Quarterly
Staleness state
Current
Question availability
Public benchmark set
BenchLM uses freshness metadata to decide whether a benchmark should still be treated as a strong differentiator, a benchmark to watch, or a display-only reference. For the full scoring policy, see the BenchLM methodology page.
FAQ
What does BioMysteryBench (human-difficult) measure?
Computational biology challenges with objective answers that remained unsolved by independent human experts.
Which model scores highest on BioMysteryBench (human-difficult)?
Claude Opus 5 by Anthropic currently leads with a score of 49.4% on BioMysteryBench (human-difficult).
How many models are evaluated on BioMysteryBench (human-difficult)?
1 AI models have been evaluated on BioMysteryBench (human-difficult) on BenchLM.