Anthropic medicinal-chemistry evaluation (Medicinal chemistry)
We show this table for reference; we do not rank on it.
Selects compounds with the highest or lowest measured ADME-related property from molecular structures and reference values.
Benchmark score on Medicinal chemistry — November 13, 2026
We compile the Medicinal chemistry rows from provider self-reports. Claude Mythos 5.2 leads the table at 69.0%, followed by Claude Sonnet 5.5 (65.3%) and Claude Opus 5.5 (63.5%). We do not use these results to rank models overall.
Claude Mythos 5.2
Anthropic
Reported by AnthropicClaude Sonnet 5.5
Anthropic
Reported by AnthropicClaude Opus 5.5
Anthropic
Reported by Anthropic4 modelsKnowledgeCurrentDisplay onlyUpdated November 13, 2026
Benchmark score table (4 models)
All 4 results on this page were reported by the labs that built the models.
| Rank | Model / configuration | Score | Who ran it | Parameters (B) | Open / closed |
|---|---|---|---|---|---|
| 1 | Claude Mythos 5.2AnthropicReported by Anthropic | 69.0% | Reported by Anthropic | Not reported | Closed |
| 2 | Claude Sonnet 5.5AnthropicReported by Anthropic | 65.3% | Reported by Anthropic | Not reported | Closed |
| 3 | Claude Opus 5.5AnthropicReported by Anthropic | 63.5% | Reported by Anthropic | Not reported | Closed |
| 4 | Claude Mythos 5.1AnthropicReported by Anthropic | 57.7% | Reported by Anthropic | Not reported | Closed |
- Lab-reported
- Benchmark-run
- Independent
Among the reported Medicinal chemistry rows, Claude Mythos 5.2 is first at 69.0%. The third row is 5.5 points behind. The broader top-10 range is 11.3 points, so the table still separates the published systems.
4 models have been evaluated on Medicinal chemistry. The benchmark falls in the Knowledge category. Medicinal chemistry is currently displayed for reference but excluded from the scoring formula, so it does not directly affect overall rankings.
About Medicinal chemistry
Year
2026
Tasks
504 molecular-property questions
Format
Accuracy
Difficulty
Medicinal chemistry reasoning
Section 8.17.4 reports a provider-run five-attempt average across 504 questions without tools. It is display-only evidence.
Freshness and provenance
Version
Medicinal chemistry 2026
Refresh cadence
Quarterly
Staleness state
Current
Question availability
Public benchmark set
BenchLM uses freshness metadata to decide whether a benchmark should still be treated as a strong differentiator, a benchmark to watch, or a display-only reference. For the full scoring policy, see the BenchLM methodology page.
Questions
What does Medicinal chemistry measure?
Selects compounds with the highest or lowest measured ADME-related property from molecular structures and reference values.
Which model scores highest on Medicinal chemistry?
Claude Mythos 5.2 by Anthropic currently leads with a score of 69.0% on Medicinal chemistry.
How many models are evaluated on Medicinal chemistry?
4 AI models have published results on Medicinal chemistry in the BenchLM catalog.
Compare top models on Medicinal chemistry
Know when it’s worth switching models
The model to choose, the cheaper alternative, and the release we would wait on.
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