Anthropic de novo protein-binder design evaluation (De novo protein-binder design)
We show this table for reference; we do not rank on it.
Designs diverse miniprotein binders against target protein structures in a GPU-equipped research sandbox.
Benchmark score on De novo protein-binder design — September 27, 2026
We compile the De novo protein-binder design rows from provider self-reports. Claude Opus 5.5 leads the table at 82.6%. We do not use these results to rank models overall.
1 modelKnowledgeCurrentDisplay onlyUpdated September 27, 2026
Benchmark score table (1 model)
ScoreAbout De novo protein-binder design
Year
2026
Tasks
15 protein targets
Format
Composite structural design score
Difficulty
Long-horizon computational protein design
Section 8.17.6 reports the mean over 15 protein targets and five independent runs per target. It is display-only, model-plus-tool-system evidence.
Freshness and provenance
Version
De novo protein-binder design 2026
Refresh cadence
Quarterly
Staleness state
Current
Question availability
Public benchmark set
BenchLM uses freshness metadata to decide whether a benchmark should still be treated as a strong differentiator, a benchmark to watch, or a display-only reference. For the full scoring policy, see the BenchLM methodology page.
Questions
What does De novo protein-binder design measure?
Designs diverse miniprotein binders against target protein structures in a GPU-equipped research sandbox.
Which model scores highest on De novo protein-binder design?
Claude Opus 5.5 by Anthropic currently leads with a score of 82.6% on De novo protein-binder design.
How many models are evaluated on De novo protein-binder design?
1 AI models have been evaluated on De novo protein-binder design on BenchLM.
Know when it’s worth switching models
The model to choose, the cheaper alternative, and the release we would wait on.
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