Protein mutation attribution (Protein Mutation Attribution)
We show this table for reference; we do not rank on it.
Anthropic's life-sciences evaluation of whether a model can attribute the effects of protein mutations.
Benchmark score on Protein Mutation Attribution — November 11, 2026
We compile the Protein Mutation Attribution rows from provider self-reports. Claude Mythos 5.2 leads the table at 51.5%, followed by Claude Opus 5.5 (49.5%) and Claude Mythos 5.1 (48.0%). We do not use these results to rank models overall.
Claude Mythos 5.2
Anthropic
Claude Opus 5.5
Anthropic
Claude Mythos 5.1
Anthropic
3 modelsKnowledgeCurrentDisplay onlyUpdated November 11, 2026
Benchmark score table (3 models)
| Rank | Model / configuration | Score | Parameters (B) | Open / closed |
|---|---|---|---|---|
| 1 | Claude Mythos 5.2Anthropic | 51.5% | Not reported | Closed |
| 2 | Claude Opus 5.5Anthropic | 49.5% | Not reported | Closed |
| 3 | Claude Mythos 5.1Anthropic | 48.0% | Not reported | Closed |
Among the reported Protein Mutation Attribution rows, Claude Mythos 5.2 is first at 51.5%. The third row is 3.5 points behind. The broader top-10 range is 3.5 points, so many of the published results sit in a relatively narrow band.
3 models have been evaluated on Protein Mutation Attribution. The benchmark falls in the Knowledge category. Protein Mutation Attribution is currently displayed for reference but excluded from the scoring formula, so it does not directly affect overall rankings.
About Protein Mutation Attribution
Year
2026
Tasks
Protein mutation questions
Format
Accuracy
Difficulty
Protein understanding
Reported in the Claude Fable 5.2 and Mythos 5.2 system card for Mythos 5.2 with biology safeguards off, against Claude Opus 5.5 and Mythos 5.1. Internal, so display-only.
Freshness and provenance
Version
Protein Mutation Attribution 2026
Refresh cadence
Quarterly
Staleness state
Current
Question availability
Public benchmark set
BenchLM uses freshness metadata to decide whether a benchmark should still be treated as a strong differentiator, a benchmark to watch, or a display-only reference. For the full scoring policy, see the BenchLM methodology page.
Questions
What does Protein Mutation Attribution measure?
Anthropic's life-sciences evaluation of whether a model can attribute the effects of protein mutations.
Which model scores highest on Protein Mutation Attribution?
Claude Mythos 5.2 by Anthropic currently leads with a score of 51.5% on Protein Mutation Attribution.
How many models are evaluated on Protein Mutation Attribution?
3 AI models have published results on Protein Mutation Attribution in the BenchLM catalog.
Compare top models on Protein Mutation Attribution
Know when it’s worth switching models
The model to choose, the cheaper alternative, and the release we would wait on.
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