Qwen2.5-72B vs Mixtral 8x22B Instruct v0.1

Side-by-side benchmark comparison across knowledge, coding, math, and reasoning.

Qwen2.5-72B is clearly ahead on the aggregate, 72 to 28. The gap is large enough that you do not need to squint at the spreadsheet to see the difference.

Qwen2.5-72B gives you the larger context window at 128K, compared with 64K for Mixtral 8x22B Instruct v0.1.

Quick Verdict

Pick Qwen2.5-72B if you want the stronger benchmark profile. Mixtral 8x22B Instruct v0.1 only becomes the better choice if knowledge is the priority.

Knowledge

Mixtral 8x22B Instruct v0.1

Qwen2.5-72B

68.2

Mixtral 8x22B Instruct v0.1

71.4

83
MMLU
71.4
82
GPQA
-
80
SuperGPQA
-
78
OpenBookQA
-
75
MMLU-Pro
-
11
HLE
-

Coding

Mixtral 8x22B Instruct v0.1

Qwen2.5-72B

53.7

Mixtral 8x22B Instruct v0.1

54.8

75
HumanEval
54.8
46
SWE-bench Verified
-
40
LiveCodeBench
-

Mathematics

Qwen2.5-72B
84
AIME 2023
-
86
AIME 2024
-
85
AIME 2025
-
80
HMMT Feb 2023
-
82
HMMT Feb 2024
-
81
HMMT Feb 2025
-
83
BRUMO 2025
-
84
MATH-500
-

Reasoning

Qwen2.5-72B
80
SimpleQA
-
78
MuSR
-
81
BBH
-

Instruction Following

Qwen2.5-72B
85
IFEval
-

Multilingual

Qwen2.5-72B
84
MGSM
-

Frequently Asked Questions

Which is better, Qwen2.5-72B or Mixtral 8x22B Instruct v0.1?

Qwen2.5-72B is ahead overall, 72 to 28. The biggest single separator in this matchup is HumanEval, where the scores are 75 and 54.8.

Which is better for knowledge tasks, Qwen2.5-72B or Mixtral 8x22B Instruct v0.1?

Mixtral 8x22B Instruct v0.1 has the edge for knowledge tasks in this comparison, averaging 71.4 versus 68.2. Inside this category, MMLU is the benchmark that creates the most daylight between them.

Which is better for coding, Qwen2.5-72B or Mixtral 8x22B Instruct v0.1?

Mixtral 8x22B Instruct v0.1 has the edge for coding in this comparison, averaging 54.8 versus 53.7. Inside this category, HumanEval is the benchmark that creates the most daylight between them.

Last updated: March 9, 2026

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