BioMysteryBench Human Difficult (BioMysteryBench (human-difficult))
We show this table for reference; we do not rank on it.
Computational biology challenges with objective answers that remained unsolved by independent human experts.
Benchmark score on BioMysteryBench (human-difficult) — September 27, 2026
We compile the BioMysteryBench (human-difficult) rows from provider self-reports. Gemini 3.8 Flash leads the table at 56.5%, followed by Claude Opus 5.5 (50.0%) and Claude Opus 5 (49.4%). We do not use these results to rank models overall.
Gemini 3.8 Flash
Claude Opus 5.5
Anthropic
Claude Opus 5
Anthropic
5 modelsKnowledgeCurrentDisplay onlyUpdated September 27, 2026
Benchmark score table (5 models)
ScoreAmong the reported BioMysteryBench (human-difficult) rows, Gemini 3.8 Flash is first at 56.5%. The third row is 7.1 points behind. The broader top-10 range is 21.2 points, so the table still separates the published systems.
5 models have been evaluated on BioMysteryBench (human-difficult). The benchmark falls in the Knowledge category. BioMysteryBench (human-difficult) is currently displayed for reference but excluded from the scoring formula, so it does not directly affect overall rankings.
About BioMysteryBench (human-difficult)
Year
2026
Tasks
Human-difficult computational biology investigations
Format
Task score
Difficulty
Frontier computational biology
Section 8.17.1 reports the provider's revised human-difficult subset after removing six problems based on external feedback.
Freshness and provenance
Version
BioMysteryBench (human-difficult) 2026
Refresh cadence
Quarterly
Staleness state
Current
Question availability
Public benchmark set
BenchLM uses freshness metadata to decide whether a benchmark should still be treated as a strong differentiator, a benchmark to watch, or a display-only reference. For the full scoring policy, see the BenchLM methodology page.
Questions
What does BioMysteryBench (human-difficult) measure?
Computational biology challenges with objective answers that remained unsolved by independent human experts.
Which model scores highest on BioMysteryBench (human-difficult)?
Gemini 3.8 Flash by Google currently leads with a score of 56.5% on BioMysteryBench (human-difficult).
How many models are evaluated on BioMysteryBench (human-difficult)?
5 AI models have been evaluated on BioMysteryBench (human-difficult) on BenchLM.
Compare top models on BioMysteryBench (human-difficult)
Know when it’s worth switching models
The model to choose, the cheaper alternative, and the release we would wait on.
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