Side-by-side benchmark comparison across knowledge, coding, math, and reasoning.
Claude 4.1 Opus is clearly ahead on the aggregate, 69 to 28. The gap is large enough that you do not need to squint at the spreadsheet to see the difference.
Claude 4.1 Opus gives you the larger context window at 200K, compared with 64K for Mixtral 8x22B Instruct v0.1.
Pick Claude 4.1 Opus if you want the stronger benchmark profile. Mixtral 8x22B Instruct v0.1 only becomes the better choice if knowledge is the priority.
Claude 4.1 Opus
64
Mixtral 8x22B Instruct v0.1
71.4
Claude 4.1 Opus
52
Mixtral 8x22B Instruct v0.1
54.8
Claude 4.1 Opus is ahead overall, 69 to 28. The biggest single separator in this matchup is HumanEval, where the scores are 68 and 54.8.
Mixtral 8x22B Instruct v0.1 has the edge for knowledge tasks in this comparison, averaging 71.4 versus 64. Inside this category, MMLU is the benchmark that creates the most daylight between them.
Mixtral 8x22B Instruct v0.1 has the edge for coding in this comparison, averaging 54.8 versus 52. Inside this category, HumanEval is the benchmark that creates the most daylight between them.
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