GPT-5.4 Pro vs Qwen2.5-72B

Side-by-side benchmark comparison across knowledge, coding, math, and reasoning.

GPT-5.4 Pro is clearly ahead on the aggregate, 94 to 72. The gap is large enough that you do not need to squint at the spreadsheet to see the difference.

GPT-5.4 Pro's sharpest advantage is in coding, where it averages 89 against 53.7. The single biggest benchmark swing on the page is LiveCodeBench, 86 to 40.

GPT-5.4 Pro is the reasoning model in the pair, while Qwen2.5-72B is not. That usually helps on harder chain-of-thought-heavy tests, but it can also mean more latency and more token spend in real use. GPT-5.4 Pro gives you the larger context window at 1.05M, compared with 128K for Qwen2.5-72B.

Quick Verdict

Pick GPT-5.4 Pro if you want the stronger benchmark profile. Qwen2.5-72B only becomes the better choice if you would rather avoid the extra latency and token burn of a reasoning model.

Knowledge

GPT-5.4 Pro

GPT-5.4 Pro

88.8

Qwen2.5-72B

68.2

99
MMLU
83
99
GPQA
82
97
SuperGPQA
80
94
OpenBookQA
78
94
MMLU-Pro
75
50
HLE
11

Coding

GPT-5.4 Pro

GPT-5.4 Pro

89

Qwen2.5-72B

53.7

95
HumanEval
75
86
SWE-bench Verified
46
86
LiveCodeBench
40

Mathematics

GPT-5.4 Pro

GPT-5.4 Pro

98

Qwen2.5-72B

83.1

99
AIME 2023
84
99
AIME 2024
86
99
AIME 2025
85
96
HMMT Feb 2023
80
98
HMMT Feb 2024
82
97
HMMT Feb 2025
81
97
BRUMO 2025
83
99
MATH-500
84

Reasoning

GPT-5.4 Pro

GPT-5.4 Pro

96.7

Qwen2.5-72B

79.7

97
SimpleQA
80
95
MuSR
78
98
BBH
81

Instruction Following

GPT-5.4 Pro

GPT-5.4 Pro

97

Qwen2.5-72B

85

97
IFEval
85

Multilingual

GPT-5.4 Pro

GPT-5.4 Pro

97

Qwen2.5-72B

84

97
MGSM
84

Frequently Asked Questions

Which is better, GPT-5.4 Pro or Qwen2.5-72B?

GPT-5.4 Pro is ahead overall, 94 to 72. The biggest single separator in this matchup is LiveCodeBench, where the scores are 86 and 40.

Which is better for knowledge tasks, GPT-5.4 Pro or Qwen2.5-72B?

GPT-5.4 Pro has the edge for knowledge tasks in this comparison, averaging 88.8 versus 68.2. Inside this category, HLE is the benchmark that creates the most daylight between them.

Which is better for coding, GPT-5.4 Pro or Qwen2.5-72B?

GPT-5.4 Pro has the edge for coding in this comparison, averaging 89 versus 53.7. Inside this category, LiveCodeBench is the benchmark that creates the most daylight between them.

Which is better for math, GPT-5.4 Pro or Qwen2.5-72B?

GPT-5.4 Pro has the edge for math in this comparison, averaging 98 versus 83.1. Inside this category, HMMT Feb 2023 is the benchmark that creates the most daylight between them.

Which is better for reasoning, GPT-5.4 Pro or Qwen2.5-72B?

GPT-5.4 Pro has the edge for reasoning in this comparison, averaging 96.7 versus 79.7. Inside this category, SimpleQA is the benchmark that creates the most daylight between them.

Which is better for instruction following, GPT-5.4 Pro or Qwen2.5-72B?

GPT-5.4 Pro has the edge for instruction following in this comparison, averaging 97 versus 85. Inside this category, IFEval is the benchmark that creates the most daylight between them.

Which is better for multilingual tasks, GPT-5.4 Pro or Qwen2.5-72B?

GPT-5.4 Pro has the edge for multilingual tasks in this comparison, averaging 97 versus 84. Inside this category, MGSM is the benchmark that creates the most daylight between them.

Last updated: March 9, 2026

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