GPT-OSS 120B vs Mixtral 8x22B Instruct v0.1

Side-by-side benchmark comparison across knowledge, coding, math, and reasoning.

GPT-OSS 120B is clearly ahead on the aggregate, 50 to 28. The gap is large enough that you do not need to squint at the spreadsheet to see the difference.

GPT-OSS 120B gives you the larger context window at 128K, compared with 64K for Mixtral 8x22B Instruct v0.1.

Quick Verdict

Pick GPT-OSS 120B if you want the stronger benchmark profile. Mixtral 8x22B Instruct v0.1 only becomes the better choice if knowledge is the priority.

Knowledge

Mixtral 8x22B Instruct v0.1

GPT-OSS 120B

43.8

Mixtral 8x22B Instruct v0.1

71.4

51
MMLU
71.4
50
GPQA
-
48
SuperGPQA
-
46
OpenBookQA
-
63
MMLU-Pro
-
5
HLE
-

Coding

Mixtral 8x22B Instruct v0.1

GPT-OSS 120B

32.3

Mixtral 8x22B Instruct v0.1

54.8

43
HumanEval
54.8
29
SWE-bench Verified
-
25
LiveCodeBench
-

Mathematics

GPT-OSS 120B
51
AIME 2023
-
53
AIME 2024
-
52
AIME 2025
-
47
HMMT Feb 2023
-
49
HMMT Feb 2024
-
48
HMMT Feb 2025
-
50
BRUMO 2025
-
71
MATH-500
-

Reasoning

GPT-OSS 120B
49
SimpleQA
-
47
MuSR
-
73
BBH
-

Instruction Following

GPT-OSS 120B
79
IFEval
-

Multilingual

GPT-OSS 120B
72
MGSM
-

Frequently Asked Questions

Which is better, GPT-OSS 120B or Mixtral 8x22B Instruct v0.1?

GPT-OSS 120B is ahead overall, 50 to 28. The biggest single separator in this matchup is MMLU, where the scores are 51 and 71.4.

Which is better for knowledge tasks, GPT-OSS 120B or Mixtral 8x22B Instruct v0.1?

Mixtral 8x22B Instruct v0.1 has the edge for knowledge tasks in this comparison, averaging 71.4 versus 43.8. Inside this category, MMLU is the benchmark that creates the most daylight between them.

Which is better for coding, GPT-OSS 120B or Mixtral 8x22B Instruct v0.1?

Mixtral 8x22B Instruct v0.1 has the edge for coding in this comparison, averaging 54.8 versus 32.3. Inside this category, HumanEval is the benchmark that creates the most daylight between them.

Last updated: March 9, 2026

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